Madhuurima made her feature film debut in Toss: A Flip of Destiny (2009). The same year she appeared in her first Telugu film. She went on to act in three Telugu projects within the next one year, including the female lead role in Vamsy's Saradaga Kasepu and a cameo role in Orange, directed by Bhaskar. However, none of the Telugu films helped her career. In 2012, her second Bollywood film Kamaal Dhamaal Malamaal directed by Priyadarshan released. Next year she appeared in two Telugu films Mahankali and Shadow. She had also signed for the Tamil remake of the Hindi film Ab Tak Chhappan, Kadamai Kanniyam Kattupadu, which was later renamed as Eepeeko, but the film was later released under the title En Vazhi Thani Vazhi (2015) and her role was removed.
2014 she was first seen in the Telugu film Veta, which was followed by her first Kannada release, Savaari 2 and her first Malayalam release, Koothara. Savaari 2 saw her playing a bank manager, while in Koothara she played the role of Shaista, an NRI. She then starred in Maruthi's Kotha Janta starring Allu Sirish and made a special appearance in Green Signal which was co-produced by Maruthi.
In early 2015, she was seen in Puri Jagannadh's Temper, and then in two Tamil films, Serndhu Polama helmed by Malayalam director Anil Kumar and Sundar C.'s Aambala. She stated that she played the central character in Temper, going on to add that the basic story revolved around her. She is working on the Telugu film, Close Friends and has completed the Malayalam film Black Coffee, in which she plays a Malayali living in Mumbai.